NOW APPROVED

A NEW THERAPY FOR ADULTS WITH ADVANCED SM

If you want to receive more information about AYVAKITTM (avapritinib), sign up here.

Welcome to AYVAKIT​

Explore the information below about this once-daily treatment for adults with advanced systemic mastocytosis (Advanced SM).

Talk to your doctor if you want to learn more about AYVAKIT or have any questions about treatment.

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What is AYVAKIT?​​

  • AYVAKIT (avapritinib) is a prescription medication used to treat adult patients with Advanced SM.
  • Avapritinib targets a genetic mutation that is the underlying cause of Advanced SM in about 95% of patients.
  • AYVAKIT is a tablet you take once per day by mouth on an empty stomach. Take AYVAKIT exactly as prescribed, and talk to your doctor if you have any questions about treatment.
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Who is AYVAKIT for?​

AYVAKIT is a treatment for adults with advanced systemic mastocytosis.

ADVANCED SM INCLUDES:

  • Aggressive systemic mastocytosis (ASM)
  • Systemic mastocytosis with an associated hematological neoplasm (SM-AHN)
  • Mast cell leukemia (MCL)

AYVAKIT is not recommended for the treatment of AdvSM in people with low platelet counts (less than 50 x 109/L).

It is not known if AYVAKIT is safe and effective in children.

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How do I take AYVAKIT?​

AYVAKIT IS TAKEN ONCE PER DAY

The recommended dose for AYVAKIT is 200 mg. Your doctor may change, temporarily stop, or permanently stop treatment with AYVAKIT if you develop side effects.

One 200-mg
AYVAKIT tablet

One time
each day

On an empty stomach, at least 1 hour before or 2 hours after a meal

Take AYVAKIT exactly as prescribed by your doctor. Do not change your dose or stop taking AYVAKIT unless your doctor tells you to. Before taking AYVAKIT, tell your doctor about all of your medical conditions and the medicines you take.

If you miss a dose of AYVAKIT, take it as soon as you remember, unless your next scheduled dose is due within 8 hours. Then, take the next dose at your regular time. If you vomit after taking a dose of AYVAKIT, do not take an extra dose. Take your next dose at your next scheduled time.

Talk to your doctor if you have questions about your treatment.

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Want to learn more about AYVAKIT?​

Download the AYVAKIT Patient Brochure for more information on Advanced SM and treatment with AYVAKIT.

This brochure is intended for digital use only. If you decide to print it, please be sure to print a copy of the full Prescribing Information as well.

If you want to know more, talk to your doctor about treatment with AYVAKIT.

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How can I get support while taking AYVAKIT?​

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YourBlueprint™ is a personalized support program designed to assist you right from the start of your treatment with AYVAKIT by providing:

  • 1-on-1 support
  • Financial assistance options
  • Helpful resources

To see how we can help

Visit YourBlueprint.com or call us at
1-888-BLUPRNT (1-888-258-7768)
Monday-Friday, 8 AM-8 PM Eastern Time (ET)

ACCESS SUPPORT
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Connect with us to receive more information about AYVAKIT​

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IMPORTANT SAFETY INFORMATION

AYVAKIT may cause serious side effects, including:

Bleeding in your brain. Serious bleeding in the brain may happen during treatment with AYVAKIT and may lead to death. Stop taking AYVAKIT and tell your healthcare provider right away if you develop any symptoms such as severe headache, vomiting, drowsiness, dizziness, confusion, or severe weakness on one or more side of your body. Your healthcare provider will check your platelet counts before and during treatment with AYVAKIT.

Cognitive effects. Cognitive side effects are common with AYVAKIT and can be severe. Tell your healthcare provider if you develop any new or worsening cognitive symptoms including forgetfulness, confusion, getting lost, trouble thinking, drowsiness, trouble staying awake (somnolence), word-finding problems, seeing objects or hearing things that are not there (hallucinations), or a change in mood or behavior.

Before taking AYVAKIT, tell your healthcare provider about all of your medical conditions, including if you:

  • have low platelet counts
  • have bulging or weakening of a blood vessel wall (aneurysm) or history of bleeding in your brain
  • have a history of stroke within the last year
  • are pregnant or plan to become pregnant. AYVAKIT can cause harm to your unborn baby
    • Females who are able to become pregnant: Your healthcare provider should do a pregnancy test before you start AYVAKIT. You should use effective birth control (contraception) during treatment with AYVAKIT and for 6 weeks after the final dose of AYVAKIT. Talk to your healthcare provider about birth control methods that may be right for you. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with AYVAKIT.
    • Males with female partners who are able to become pregnant should use effective birth control (contraception) during treatment and for 6 weeks after the final dose of AYVAKIT.
  • are breastfeeding or plan to breastfeed. It is not known if AYVAKIT passes into your breast milk. Do not breastfeed during treatment with AYVAKIT and for at least 2 weeks after the final dose of AYVAKIT. Talk to your healthcare provider about the best way to feed your baby during this time

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. AYVAKIT may affect the way other medicines work, and certain other medicines may affect how AYVAKIT works. Talk to your healthcare provider prior to starting a new medicine.

Do not drive or operate hazardous machinery if you have confusion or trouble thinking during treatment with AYVAKIT.

The most common side effects of AYVAKIT in people with AdvSM include fluid retention or swelling, diarrhea, nausea, tiredness, and changes in certain blood tests.

Your healthcare provider may change your dose, temporarily stop, or permanently stop treatment with AYVAKIT if you develop certain side effects. AYVAKIT may cause fertility problems in females and may decrease sperm production in males, which may affect your ability to have a child. Talk to your healthcare provider if this is a concern for you. These are not all of the possible side effects of AYVAKIT. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

INDICATION

AYVAKIT™ (avapritinib) is a prescription medicine used to treat adults with advanced systemic mastocytosis (AdvSM), including aggressive systemic mastocytosis (ASM), systemic mastocytosis with an associated hematological neoplasm (SM-AHN), and mast cell leukemia (MCL). AYVAKIT is not recommended for the treatment of AdvSM in people with low platelet counts (less than 50 x 109/L). It is not known if AYVAKIT is safe and effective in children.

Please see the full Prescribing Information and Patient Information for AYVAKIT.